258989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2354632..2355158 Replicon chromosome
Accession NZ_CP104681
Organism Escherichia coli strain 2022CK-00450

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N5922_RS11495 Protein ID WP_000323025.1
Coordinates 2354871..2355158 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N5922_RS11490 Protein ID WP_000534858.1
Coordinates 2354632..2354871 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5922_RS11460 (2349964) 2349964..2350453 + 490 Protein_2242 class I SAM-dependent methyltransferase -
N5922_RS11465 (2350931) 2350931..2351352 + 422 Protein_2243 hypothetical protein -
N5922_RS11470 (2351987) 2351987..2352358 + 372 WP_001406656.1 helix-turn-helix domain-containing protein -
N5922_RS11475 (2353181) 2353181..2353330 + 150 WP_011443592.1 protein YdfW -
N5922_RS11480 (2353767) 2353767..2354099 - 333 WP_001317460.1 FlxA-like family protein -
N5922_RS11485 (2354302) 2354302..2354607 - 306 WP_001326990.1 protein YdfV -
N5922_RS11490 (2354632) 2354632..2354871 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N5922_RS11495 (2354871) 2354871..2355158 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N5922_RS11500 (2355230) 2355230..2355385 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N5922_RS11505 (2355602) 2355602..2355853 + 252 WP_000980994.1 protein Rem -
N5922_RS11510 (2355920) 2355920..2356198 + 279 WP_012304870.1 hypothetical protein -
N5922_RS11515 (2356200) 2356200..2357249 + 1050 WP_001265198.1 DUF968 domain-containing protein -
N5922_RS11520 (2357263) 2357263..2358015 + 753 WP_001047135.1 antitermination protein -
N5922_RS11525 (2358293) 2358293..2358382 - 90 WP_120795389.1 hypothetical protein -
N5922_RS11530 (2358437) 2358437..2358649 - 213 WP_000087756.1 cold shock-like protein CspF -
N5922_RS11535 (2358950) 2358950..2359165 + 216 WP_000066484.1 cold shock-like protein CspB -
N5922_RS11540 (2359529) 2359529..2359699 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
N5922_RS11545 (2359919) 2359919..2360134 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2328954..2380692 51738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T258989 WP_000323025.1 NZ_CP104681:2354871-2355158 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT258989 WP_000534858.1 NZ_CP104681:2354632-2354871 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References