Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2354632..2355158 Replicon chromosome
Accession NZ_CP104681
Organism Escherichia coli strain 2022CK-00450

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N5922_RS11495 Protein ID WP_000323025.1
Coordinates 2354871..2355158 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N5922_RS11490 Protein ID WP_000534858.1
Coordinates 2354632..2354871 (+) Length 80 a.a.

Genomic Context

N5922_RS11460N5922_RS11465N5922_RS11470N5922_RS11475N5922_RS11490N5922_RS11495N5922_RS11500N5922_RS11505N5922_RS11510N5922_RS11515N5922_RS11520N5922_RS11535N5922_RS11545N5922_RS11480N5922_RS11485N5922_RS11525N5922_RS11530N5922_RS11540
Location: 2349964..2350453 (490 bp)
Type: Others
Protein ID: Protein_2242
Location: 2350931..2351352 (422 bp)
Type: Others
Protein ID: Protein_2243
Location: 2351987..2352358 (372 bp)
Type: Others
Protein ID: WP_001406656.1
Location: 2353181..2353330 (150 bp)
Type: Others
Protein ID: WP_011443592.1
Location: 2354632..2354871 (240 bp)
Type: Antitoxin
Protein ID: WP_000534858.1
Location: 2354871..2355158 (288 bp)
Type: Toxin
Protein ID: WP_000323025.1
Location: 2355230..2355385 (156 bp)
Type: Others
Protein ID: WP_000813254.1
Location: 2355602..2355853 (252 bp)
Type: Others
Protein ID: WP_000980994.1
Location: 2355920..2356198 (279 bp)
Type: Others
Protein ID: WP_012304870.1
Location: 2356200..2357249 (1050 bp)
Type: Others
Protein ID: WP_001265198.1
Location: 2357263..2358015 (753 bp)
Type: Others
Protein ID: WP_001047135.1
Location: 2358950..2359165 (216 bp)
Type: Others
Protein ID: WP_000066484.1
Location: 2359919..2360134 (216 bp)
Type: Others
Protein ID: WP_000839590.1
Location: 2353767..2354099 (333 bp)
Type: Others
Protein ID: WP_001317460.1
Location: 2354302..2354607 (306 bp)
Type: Others
Protein ID: WP_001326990.1
Location: 2358293..2358382 (90 bp)
Type: Others
Protein ID: WP_120795389.1
Location: 2358437..2358649 (213 bp)
Type: Others
Protein ID: WP_000087756.1
Location: 2359529..2359699 (171 bp)
Type: Others
Protein ID: WP_211180497.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N5922_RS11460 (2349964)2349964..2350453+490Protein_2242class I SAM-dependent methyltransferase-
N5922_RS11465 (2350931)2350931..2351352+422Protein_2243hypothetical protein-
N5922_RS11470 (2351987)2351987..2352358+372WP_001406656.1helix-turn-helix domain-containing protein-
N5922_RS11475 (2353181)2353181..2353330+150WP_011443592.1protein YdfW-
N5922_RS11480 (2353767)2353767..2354099-333WP_001317460.1FlxA-like family protein-
N5922_RS11485 (2354302)2354302..2354607-306WP_001326990.1protein YdfV-
N5922_RS11490 (2354632)2354632..2354871+240WP_000534858.1type II toxin-antitoxin system antitoxin RelBAntitoxin
N5922_RS11495 (2354871)2354871..2355158+288WP_000323025.1type II toxin-antitoxin system mRNA interferase RelEToxin
N5922_RS11500 (2355230)2355230..2355385+156WP_000813254.1type I toxin-antitoxin system toxin HokD-
N5922_RS11505 (2355602)2355602..2355853+252WP_000980994.1protein Rem-
N5922_RS11510 (2355920)2355920..2356198+279WP_012304870.1hypothetical protein-
N5922_RS11515 (2356200)2356200..2357249+1050WP_001265198.1DUF968 domain-containing protein-
N5922_RS11520 (2357263)2357263..2358015+753WP_001047135.1antitermination protein-
N5922_RS11525 (2358293)2358293..2358382-90WP_120795389.1hypothetical protein-
N5922_RS11530 (2358437)2358437..2358649-213WP_000087756.1cold shock-like protein CspF-
N5922_RS11535 (2358950)2358950..2359165+216WP_000066484.1cold shock-like protein CspB-
N5922_RS11540 (2359529)2359529..2359699-171WP_211180497.1putative zinc-binding protein YnfU-
N5922_RS11545 (2359919)2359919..2360134+216WP_000839590.1phage lysis protein EssD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2328954..238069251738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T258989 WP_000323025.1 NZ_CP104681:2354871-2355158 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT258989 WP_000534858.1 NZ_CP104681:2354632-2354871 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4V7K
PDB4V7J
PDB4FXI
PDB4FXE
PDB2KC8
PDB4FXH
PDB2KC9

Antitoxin

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Source
ID
Structure
PDB4FXE
PDB2KC8
PDB2K29
AlphaFold DBA0A4V1CTS8

References