Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4872164..4872680 Replicon chromosome
Accession NZ_CP104678
Organism Klebsiella pneumoniae strain 2021CK-00608

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag N5933_RS23790 Protein ID WP_004178374.1
Coordinates 4872164..4872448 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N5933_RS23795 Protein ID WP_002886901.1
Coordinates 4872438..4872680 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5933_RS23765 (4867648) 4867648..4867911 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
N5933_RS23770 (4868041) 4868041..4868214 + 174 WP_032408826.1 hypothetical protein -
N5933_RS23775 (4868217) 4868217..4868960 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N5933_RS23780 (4869317) 4869317..4871455 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N5933_RS23785 (4871696) 4871696..4872160 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N5933_RS23790 (4872164) 4872164..4872448 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5933_RS23795 (4872438) 4872438..4872680 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5933_RS23800 (4872758) 4872758..4874668 - 1911 WP_004178373.1 PRD domain-containing protein -
N5933_RS23805 (4874691) 4874691..4875845 - 1155 WP_004178372.1 lactonase family protein -
N5933_RS23810 (4875912) 4875912..4876652 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T258972 WP_004178374.1 NZ_CP104678:c4872448-4872164 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT258972 WP_002886901.1 NZ_CP104678:c4872680-4872438 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References