Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2710046..2711634 Replicon chromosome
Accession NZ_CP104678
Organism Klebsiella pneumoniae strain 2021CK-00608

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5933_RS13385 Protein ID WP_004179815.1
Coordinates 2710046..2711368 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5933_RS13390 Protein ID WP_004176198.1
Coordinates 2711368..2711634 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5933_RS13370 (2705102) 2705102..2707603 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
N5933_RS13375 (2707591) 2707591..2708595 + 1005 WP_004179822.1 fimbrial protein -
N5933_RS13380 (2708737) 2708737..2710029 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N5933_RS13385 (2710046) 2710046..2711368 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
N5933_RS13390 (2711368) 2711368..2711634 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5933_RS13395 (2711900) 2711900..2712226 - 327 WP_002904788.1 hydroxyisourate hydrolase -
N5933_RS13400 (2712223) 2712223..2712723 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N5933_RS13405 (2712701) 2712701..2714080 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
N5933_RS13410 (2714426) 2714426..2715580 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N5933_RS13415 (2715561) 2715561..2716484 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T258967 WP_004179815.1 NZ_CP104678:c2711368-2710046 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT258967 WP_004176198.1 NZ_CP104678:c2711634-2711368 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References