Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 845371..846028 Replicon chromosome
Accession NZ_CP104678
Organism Klebsiella pneumoniae strain 2021CK-00608

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N5933_RS04180 Protein ID WP_002916310.1
Coordinates 845618..846028 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N5933_RS04175 Protein ID WP_002916312.1
Coordinates 845371..845637 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5933_RS04150 (840527) 840527..841960 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
N5933_RS04155 (842079) 842079..842807 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N5933_RS04160 (842857) 842857..843168 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
N5933_RS04165 (843332) 843332..843991 + 660 WP_002916317.1 hemolysin III family protein -
N5933_RS04170 (844142) 844142..845125 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
N5933_RS04175 (845371) 845371..845637 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N5933_RS04180 (845618) 845618..846028 + 411 WP_002916310.1 protein YgfX Toxin
N5933_RS04185 (846035) 846035..846556 - 522 WP_004144730.1 flavodoxin FldB -
N5933_RS04190 (846657) 846657..847553 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N5933_RS04195 (847576) 847576..848289 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5933_RS04200 (848295) 848295..850028 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T258962 WP_002916310.1 NZ_CP104678:845618-846028 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT258962 WP_002916312.1 NZ_CP104678:845371-845637 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References