Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 695455..696134 Replicon chromosome
Accession NZ_CP104678
Organism Klebsiella pneumoniae strain 2021CK-00608

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag N5933_RS03415 Protein ID WP_020324801.1
Coordinates 695793..696134 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag N5933_RS03410 Protein ID WP_020324792.1
Coordinates 695455..695772 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5933_RS03385 (690669) 690669..693821 + 3153 WP_022631414.1 AIDA repeat-containing protein -
N5933_RS03390 (693914) 693914..694153 + 240 WP_020324820.1 DUF905 domain-containing protein -
N5933_RS03395 (694256) 694256..694714 + 459 WP_261658308.1 antirestriction protein -
N5933_RS03400 (694730) 694730..695206 + 477 WP_020324797.1 RadC family protein -
N5933_RS03405 (695215) 695215..695442 + 228 WP_020324796.1 DUF987 domain-containing protein -
N5933_RS03410 (695455) 695455..695772 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N5933_RS03415 (695793) 695793..696134 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
N5933_RS03420 (696250) 696250..697083 + 834 WP_020324805.1 DUF4942 domain-containing protein -
N5933_RS03430 (697386) 697386..697892 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
N5933_RS03435 (697992) 697992..699833 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / fimI / fimC / fimD / fimD / fimF / fimG 647513..697083 49570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T258961 WP_020324801.1 NZ_CP104678:695793-696134 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT258961 WP_020324792.1 NZ_CP104678:695455-695772 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References