Detailed information of TA system TA025896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384279..1384967
• Replicon: chromosome
• Accession: NC_016804
• Organism: Mycobacterium bovis BCG str. Mexico

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: BCGMEX_RS06575
• Protein ID: WP_003406304.1
• Coordinates: 1384536..1384967 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: BCGMEX_RS06570
• Protein ID: WP_003406302.1
• Coordinates: 1384279..1384539 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCGMEX_RS06550	1379856..1380680	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
BCGMEX_RS06555	1380685..1381866	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
BCGMEX_RS06560	1381943..1383043	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
BCGMEX_RS06565	1383214..1384203	+	990	WP_003406301.1	malate dehydrogenase	-
BCGMEX_RS06570	1384279..1384539	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
BCGMEX_RS06575	1384536..1384967	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
BCGMEX_RS06580	1384990..1386678	-	1689	WP_003910308.1	PE family protein	-
BCGMEX_RS06585	1386858..1387718	+	861	WP_003406306.1	hypothetical protein	-
BCGMEX_RS06590	1387799..1388629	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
BCGMEX_RS06595	1388686..1388979	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
BCGMEX_RS06600	1388976..1389245	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T25896 WP_003406304.1 NC_016804:1384536-1384967 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T25896 NC_016804:1384536-1384967 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT25896 WP_003406302.1 NC_016804:1384279-1384539 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT25896 NC_016804:1384279-1384539 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6