Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4214985..4215766 Replicon chromosome
Accession NZ_CP104677
Organism Salmonella enterica strain PNUSAS036471

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag N4534_RS20575 Protein ID WP_000625912.1
Coordinates 4214985..4215476 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag N4534_RS20580 Protein ID WP_001110450.1
Coordinates 4215473..4215766 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4534_RS20550 (4211867) 4211867..4212697 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
N4534_RS20555 (4212899) 4212899..4213174 - 276 WP_001281414.1 PapB/FocB family fimbrial expression transcriptional regulator -
N4534_RS20560 (4213735) 4213735..4213878 + 144 Protein_4019 transposase -
N4534_RS20565 (4213895) 4213895..4214241 + 347 Protein_4020 Rpn family recombination-promoting nuclease/putative transposase -
N4534_RS20570 (4214522) 4214522..4214770 - 249 Protein_4021 IS481 family transposase -
N4534_RS20575 (4214985) 4214985..4215476 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
N4534_RS20580 (4215473) 4215473..4215766 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
N4534_RS20585 (4216083) 4216083..4216305 + 223 Protein_4024 hypothetical protein -
N4534_RS20590 (4216569) 4216569..4217444 + 876 WP_000921676.1 AraC family transcriptional regulator -
N4534_RS20595 (4217441) 4217441..4217728 + 288 WP_001269916.1 transcriptional regulator RtsB -
N4534_RS20600 (4217721) 4217721..4217903 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
N4534_RS20605 (4217923) 4217923..4218022 + 100 Protein_4028 hypothetical protein -
N4534_RS20610 (4218136) 4218136..4218270 + 135 Protein_4029 hypothetical protein -
N4534_RS20615 (4218565) 4218565..4219470 - 906 WP_129429071.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4208074..4217728 9654
- inside Genomic island - - 4208074..4217903 9829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T258957 WP_000625912.1 NZ_CP104677:c4215476-4214985 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT258957 WP_001110450.1 NZ_CP104677:c4215766-4215473 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References