Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4097579..4098095 Replicon chromosome
Accession NZ_CP104677
Organism Salmonella enterica strain PNUSAS036471

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag N4534_RS19930 Protein ID WP_000220578.1
Coordinates 4097579..4097863 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N4534_RS19935 Protein ID WP_000212724.1
Coordinates 4097853..4098095 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4534_RS19915 (4092791) 4092791..4094443 + 1653 WP_000155045.1 alpha,alpha-phosphotrehalase -
N4534_RS19920 (4094852) 4094852..4096990 + 2139 WP_000187825.1 anaerobic ribonucleoside-triphosphate reductase -
N4534_RS19925 (4097111) 4097111..4097575 + 465 WP_001268864.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4534_RS19930 (4097579) 4097579..4097863 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4534_RS19935 (4097853) 4097853..4098095 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4534_RS19940 (4098173) 4098173..4100086 - 1914 WP_001212150.1 BglG family transcription antiterminator -
N4534_RS19945 (4100103) 4100103..4100843 - 741 WP_000779258.1 KDGP aldolase family protein -
N4534_RS19950 (4100840) 4100840..4101958 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N4534_RS19955 (4101942) 4101942..4103075 - 1134 WP_000459939.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T258956 WP_000220578.1 NZ_CP104677:c4097863-4097579 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258956 WP_000212724.1 NZ_CP104677:c4098095-4097853 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References