Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3409732..3410352 Replicon chromosome
Accession NZ_CP104677
Organism Salmonella enterica strain PNUSAS036471

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4534_RS16765 Protein ID WP_001280991.1
Coordinates 3410134..3410352 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4534_RS16760 Protein ID WP_000344807.1
Coordinates 3409732..3410106 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4534_RS16750 (3404871) 3404871..3406064 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4534_RS16755 (3406087) 3406087..3409236 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N4534_RS16760 (3409732) 3409732..3410106 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4534_RS16765 (3410134) 3410134..3410352 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4534_RS16770 (3410531) 3410531..3411082 + 552 WP_001278792.1 maltose O-acetyltransferase -
N4534_RS16775 (3411199) 3411199..3411669 + 471 WP_000136181.1 YlaC family protein -
N4534_RS16780 (3411725) 3411725..3411865 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N4534_RS16785 (3411871) 3411871..3412131 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N4534_RS16790 (3412356) 3412356..3413906 + 1551 WP_000213138.1 EAL domain-containing protein -
N4534_RS16800 (3414137) 3414137..3414526 + 390 WP_000961287.1 MGMT family protein -
N4534_RS16805 (3414559) 3414559..3415128 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258953 WP_001280991.1 NZ_CP104677:3410134-3410352 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258953 WP_000344807.1 NZ_CP104677:3409732-3410106 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References