Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 809911..810536 Replicon chromosome
Accession NZ_CP104677
Organism Salmonella enterica strain PNUSAS036471

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4534_RS03935 Protein ID WP_000911337.1
Coordinates 810138..810536 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag N4534_RS03930 Protein ID WP_000557545.1
Coordinates 809911..810138 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4534_RS03900 (804956) 804956..806473 + 1518 WP_000003339.1 lysine--tRNA ligase -
N4534_RS03905 (806549) 806549..807094 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
N4534_RS03910 (807359) 807359..808117 + 759 WP_000244328.1 amidase activator ActS -
N4534_RS03920 (808402) 808402..809208 - 807 WP_079848076.1 DUF1460 domain-containing protein -
N4534_RS03925 (809483) 809483..809734 - 252 WP_001540858.1 hypothetical protein -
N4534_RS03930 (809911) 809911..810138 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4534_RS03935 (810138) 810138..810536 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
N4534_RS03940 (811343) 811343..811879 + 537 WP_001038502.1 STM3031 family outer membrane protein -
N4534_RS03945 (811926) 811926..812558 + 633 WP_000835265.1 YfdX family protein -
N4534_RS03950 (813277) 813277..813858 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 809483..818330 8847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T258947 WP_000911337.1 NZ_CP104677:810138-810536 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT258947 WP_000557545.1 NZ_CP104677:809911-810138 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References