Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799024..799684 Replicon chromosome
Accession NZ_CP104677
Organism Salmonella enterica strain PNUSAS036471

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag N4534_RS03870 Protein ID WP_000244756.1
Coordinates 799271..799684 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag N4534_RS03865 Protein ID WP_000351186.1
Coordinates 799024..799290 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4534_RS03845 (794956) 794956..796389 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
N4534_RS03850 (796544) 796544..796858 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
N4534_RS03855 (797019) 797019..797678 + 660 WP_000250289.1 hemolysin III family protein -
N4534_RS03860 (797794) 797794..798774 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
N4534_RS03865 (799024) 799024..799290 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
N4534_RS03870 (799271) 799271..799684 + 414 WP_000244756.1 protein YgfX Toxin
N4534_RS03875 (799737) 799737..800258 - 522 WP_001055885.1 flavodoxin FldB -
N4534_RS03880 (800371) 800371..801267 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
N4534_RS03885 (801291) 801291..802004 + 714 WP_000745621.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4534_RS03890 (802010) 802010..803743 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T258946 WP_000244756.1 NZ_CP104677:799271-799684 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT258946 WP_000351186.1 NZ_CP104677:799024-799290 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References