Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 83155..83799 Replicon plasmid unnamed2
Accession NZ_CP104667
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name hicA Uniprot ID A0A1C0Y1A0
Locus tag N5914_RS25955 Protein ID WP_029701816.1
Coordinates 83155..83337 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M2I339
Locus tag N5914_RS25960 Protein ID WP_072770518.1
Coordinates 83368..83799 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS25935 (N5914_25945) 78426..78650 - 225 WP_021551764.1 host cell division inhibitor Icd-like protein -
N5914_RS25940 (N5914_25950) 79066..80025 - 960 WP_124062617.1 lytic replication protein -
N5914_RS25945 (N5914_25955) 80225..81223 - 999 WP_021551762.1 hypothetical protein -
N5914_RS25950 (N5914_25960) 81237..82922 - 1686 WP_068862842.1 portal protein -
N5914_RS25955 (N5914_25965) 83155..83337 + 183 WP_029701816.1 type II toxin-antitoxin system HicA family toxin Toxin
N5914_RS25960 (N5914_25970) 83368..83799 + 432 WP_072770518.1 hypothetical protein Antitoxin
N5914_RS25965 (N5914_25975) 83912..85297 - 1386 WP_029701814.1 hypothetical protein -
N5914_RS25970 (N5914_25980) 85389..85757 - 369 WP_029701812.1 hypothetical protein -
N5914_RS25975 (N5914_25985) 85754..87706 - 1953 WP_062876065.1 hypothetical protein -
N5914_RS25980 (N5914_25990) 87703..88320 - 618 WP_021551755.1 hypothetical protein -
N5914_RS25985 (N5914_25995) 88310..88756 - 447 WP_016262345.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91750 91750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6850.97 Da        Isoelectric Point: 10.9041

>T258943 WP_029701816.1 NZ_CP104667:83155-83337 [Escherichia coli]
VKYSEFKRWLIQQGAEFRKAPGGGSHQKVNLNGKRSVFPDHGSKEMPEPLRKKIMKDLGL

Download         Length: 183 bp

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15627.95 Da        Isoelectric Point: 5.2844

>AT258943 WP_072770518.1 NZ_CP104667:83368-83799 [Escherichia coli]
MFNYPVKLERDDKTGAYVVSCRDLPLFNSVGDSVEEALLEAGYGLVAAVAIEIEERRPVPTGSEPKEGEYVVSLPVLPAM
KAALHNAMIETGTRKAELARKLGKNGTQIDRLLDVEHSSKVETVELALHQLNKNIAVSVTPMR

Download         Length: 432 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y1A0

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2I339

References