258940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 55752..56377 Replicon plasmid unnamed1
Accession NZ_CP104666
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D7QA53
Locus tag N5914_RS24985 Protein ID WP_039023147.1
Coordinates 55979..56377 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D7QA08
Locus tag N5914_RS24980 Protein ID WP_039023146.1
Coordinates 55752..55979 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS24980 (55752) 55752..55979 + 228 WP_039023146.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5914_RS24985 (55979) 55979..56377 + 399 WP_039023147.1 type II toxin-antitoxin system VapC family toxin Toxin
N5914_RS24990 (56386) 56386..58557 - 2172 WP_121350052.1 type IV conjugative transfer system coupling protein TraD -
N5914_RS24995 (58810) 58810..59541 - 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
N5914_RS25000 (59573) 59573..60070 - 498 WP_000605862.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / erm(B) / dfrA12 / aadA2 / qacE / sul1 / blaNDM-5 / mph(A) / aadA5 / tet(B) - 1..131846 131846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14885.26 Da        Isoelectric Point: 8.2824

>T258940 WP_039023147.1 NZ_CP104666:55979-56377 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAAIHT
GQIRAELARQGRPVGPFDQMIAGHARCRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8549.62 Da        Isoelectric Point: 4.7513

>AT258940 WP_039023146.1 NZ_CP104666:55752-55979 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAIGRTRLITPAGETWDEWFDGHSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7QA53

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7QA08

References