Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4499331..4499926 Replicon chromosome
Accession NZ_CP104665
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag N5914_RS21680 Protein ID WP_000239581.1
Coordinates 4499331..4499681 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag N5914_RS21685 Protein ID WP_001223213.1
Coordinates 4499675..4499926 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS21660 (4494384) 4494384..4495886 - 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
N5914_RS21665 (4496093) 4496093..4497439 + 1347 WP_000483767.1 IS4-like element IS4 family transposase -
N5914_RS21670 (4497456) 4497456..4498412 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N5914_RS21675 (4498722) 4498722..4499252 + 531 WP_000055075.1 inorganic diphosphatase -
N5914_RS21680 (4499331) 4499331..4499681 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
N5914_RS21685 (4499675) 4499675..4499926 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N5914_RS21690 (4500138) 4500138..4500479 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N5914_RS21695 (4500482) 4500482..4504261 - 3780 WP_022646473.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4496111..4497439 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T258933 WP_000239581.1 NZ_CP104665:c4499681-4499331 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT258933 WP_001223213.1 NZ_CP104665:c4499926-4499675 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References