Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4198097..4198647 | Replicon | chromosome |
Accession | NZ_CP104665 | ||
Organism | Escherichia coli strain 2021CK-00607 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | N5914_RS20230 | Protein ID | WP_001160966.1 |
Coordinates | 4198097..4198411 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1NMQ0 |
Locus tag | N5914_RS20235 | Protein ID | WP_000125568.1 |
Coordinates | 4198414..4198647 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5914_RS20205 (4193772) | 4193772..4195058 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
N5914_RS20210 (4195058) | 4195058..4196047 | + | 990 | WP_000241224.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
N5914_RS20215 (4196044) | 4196044..4196865 | + | 822 | WP_001065381.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
N5914_RS20220 (4196868) | 4196868..4197245 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
N5914_RS20225 (4197252) | 4197252..4198100 | + | 849 | WP_000257195.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
N5914_RS20230 (4198097) | 4198097..4198411 | - | 315 | WP_001160966.1 | CcdB family protein | Toxin |
N5914_RS20235 (4198414) | 4198414..4198647 | - | 234 | WP_000125568.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
N5914_RS20240 (4198733) | 4198733..4199212 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
N5914_RS20245 (4199404) | 4199404..4201266 | - | 1863 | WP_022645165.1 | glutathione-regulated potassium-efflux system protein KefC | - |
N5914_RS20250 (4201259) | 4201259..4201789 | - | 531 | WP_000600732.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
N5914_RS20255 (4201897) | 4201897..4203228 | - | 1332 | WP_001183201.1 | MFS transporter | - |
N5914_RS20260 (4203286) | 4203286..4203573 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T258927 WP_001160966.1 NZ_CP104665:c4198411-4198097 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829GEF2 |