258925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3775136..3775754 Replicon chromosome
Accession NZ_CP104665
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5914_RS18235 Protein ID WP_001291435.1
Coordinates 3775536..3775754 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5914_RS18230 Protein ID WP_000344800.1
Coordinates 3775136..3775510 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS18220 (3770225) 3770225..3771418 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5914_RS18225 (3771441) 3771441..3774590 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5914_RS18230 (3775136) 3775136..3775510 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5914_RS18235 (3775536) 3775536..3775754 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5914_RS18240 (3775926) 3775926..3776477 + 552 WP_000102574.1 maltose O-acetyltransferase -
N5914_RS18245 (3776593) 3776593..3777063 + 471 WP_022645280.1 YlaC family protein -
N5914_RS18250 (3777227) 3777227..3778777 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5914_RS18255 (3778819) 3778819..3779172 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N5914_RS18265 (3779551) 3779551..3779862 + 312 WP_000409911.1 MGMT family protein -
N5914_RS18270 (3779893) 3779893..3780465 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258925 WP_001291435.1 NZ_CP104665:3775536-3775754 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258925 WP_000344800.1 NZ_CP104665:3775136-3775510 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References