Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2634082..2634720 Replicon chromosome
Accession NZ_CP104665
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5914_RS12515 Protein ID WP_000813794.1
Coordinates 2634544..2634720 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5914_RS12510 Protein ID WP_001270286.1
Coordinates 2634082..2634498 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS12490 (2629234) 2629234..2630175 - 942 WP_022645667.1 ABC transporter permease -
N5914_RS12495 (2630176) 2630176..2631189 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
N5914_RS12500 (2631207) 2631207..2632352 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
N5914_RS12505 (2632597) 2632597..2634003 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
N5914_RS12510 (2634082) 2634082..2634498 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5914_RS12515 (2634544) 2634544..2634720 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5914_RS12520 (2634942) 2634942..2635172 + 231 WP_000491567.1 DUF2554 family protein -
N5914_RS12525 (2635264) 2635264..2637225 - 1962 WP_022645664.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5914_RS12530 (2637298) 2637298..2637834 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
N5914_RS12535 (2637926) 2637926..2639098 + 1173 WP_022645663.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258921 WP_000813794.1 NZ_CP104665:c2634720-2634544 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258921 WP_001270286.1 NZ_CP104665:c2634498-2634082 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References