Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4819753..4820269 Replicon chromosome
Accession NZ_CP104660
Organism Klebsiella pneumoniae strain 2021CK-01729

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag N4T33_RS23150 Protein ID WP_009486548.1
Coordinates 4819753..4820037 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A331AB37
Locus tag N4T33_RS23155 Protein ID WP_019704689.1
Coordinates 4820027..4820269 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T33_RS23125 (N4T33_23130) 4815149..4815412 - 264 WP_020802733.1 PTS sugar transporter subunit IIB -
N4T33_RS23130 (N4T33_23135) 4815542..4815655 + 114 Protein_4536 hypothetical protein -
N4T33_RS23135 (N4T33_23140) 4815718..4816461 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N4T33_RS23140 (N4T33_23145) 4816818..4818956 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N4T33_RS23145 (N4T33_23150) 4819285..4819749 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4T33_RS23150 (N4T33_23155) 4819753..4820037 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4T33_RS23155 (N4T33_23160) 4820027..4820269 - 243 WP_019704689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4T33_RS23160 (N4T33_23165) 4820347..4822257 - 1911 WP_004152270.1 PRD domain-containing protein -
N4T33_RS23165 (N4T33_23170) 4822280..4823434 - 1155 WP_019704690.1 lactonase family protein -
N4T33_RS23170 (N4T33_23175) 4823501..4824241 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T258907 WP_009486548.1 NZ_CP104660:c4820037-4819753 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9044.56 Da        Isoelectric Point: 8.5313

>AT258907 WP_019704689.1 NZ_CP104660:c4820269-4820027 [Klebsiella pneumoniae]
MATLNVRLDDKLKKQAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A331AB37

References