Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2798970..2800558 Replicon chromosome
Accession NZ_CP104660
Organism Klebsiella pneumoniae strain 2021CK-01729

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N4T33_RS13595 Protein ID WP_019705665.1
Coordinates 2798970..2800292 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N4T33_RS13600 Protein ID WP_004176198.1
Coordinates 2800292..2800558 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T33_RS13580 (N4T33_13580) 2794026..2796527 + 2502 WP_019705666.1 fimbria/pilus outer membrane usher protein -
N4T33_RS13585 (N4T33_13585) 2796515..2797519 + 1005 WP_004184029.1 fimbrial protein -
N4T33_RS13590 (N4T33_13590) 2797661..2798953 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N4T33_RS13595 (N4T33_13595) 2798970..2800292 - 1323 WP_019705665.1 type II toxin-antitoxin system HipA family toxin Toxin
N4T33_RS13600 (N4T33_13600) 2800292..2800558 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N4T33_RS13605 (N4T33_13605) 2800824..2801150 - 327 WP_019705664.1 hydroxyisourate hydrolase -
N4T33_RS13610 (N4T33_13610) 2801147..2801647 - 501 WP_019705663.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N4T33_RS13615 (N4T33_13615) 2801625..2803004 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
N4T33_RS13620 (N4T33_13620) 2803350..2804504 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N4T33_RS13625 (N4T33_13625) 2804485..2805408 - 924 WP_019705662.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T258903 WP_019705665.1 NZ_CP104660:c2800292-2798970 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT258903 WP_004176198.1 NZ_CP104660:c2800558-2800292 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References