Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4613367..4614070 Replicon chromosome
Accession NZ_CP104659
Organism Klebsiella pneumoniae strain 2020CK-00096

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag N5936_RS22420 Protein ID WP_071994632.1
Coordinates 4613729..4614070 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag N5936_RS22415 Protein ID WP_032434296.1
Coordinates 4613367..4613708 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5936_RS22380 (4608522) 4608522..4609396 + 875 Protein_4368 GTPase family protein -
N5936_RS22385 (4609640) 4609640..4610356 + 717 WP_032434305.1 WYL domain-containing protein -
N5936_RS22390 (4610392) 4610392..4610844 + 453 WP_032410767.1 hypothetical protein -
N5936_RS22395 (4610916) 4610916..4611389 + 474 WP_032434303.1 hypothetical protein -
N5936_RS22400 (4611509) 4611509..4612330 + 822 WP_032434301.1 DUF932 domain-containing protein -
N5936_RS22405 (4612361) 4612361..4612801 + 441 WP_032434300.1 antirestriction protein -
N5936_RS22410 (4612814) 4612814..4613356 + 543 WP_032434298.1 DNA repair protein RadC -
N5936_RS22415 (4613367) 4613367..4613708 + 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N5936_RS22420 (4613729) 4613729..4614070 + 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
N5936_RS22425 (4614262) 4614262..4616295 - 2034 WP_050598589.1 hypothetical protein -
N5936_RS22430 (4616886) 4616886..4617755 - 870 WP_023317468.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCTX-M-15 - 4577797..4626351 48554


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T258893 WP_071994632.1 NZ_CP104659:4613729-4614070 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT258893 WP_032434296.1 NZ_CP104659:4613367-4613708 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References