Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4517848..4518364 Replicon chromosome
Accession NZ_CP104659
Organism Klebsiella pneumoniae strain 2020CK-00096

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag N5936_RS22015 Protein ID WP_004178374.1
Coordinates 4518080..4518364 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag N5936_RS22010 Protein ID WP_032434351.1
Coordinates 4517848..4518090 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5936_RS21995 (4513877) 4513877..4514617 + 741 WP_002886899.1 KDGP aldolase family protein -
N5936_RS22000 (4514683) 4514683..4515837 + 1155 WP_002886900.1 lactonase family protein -
N5936_RS22005 (4515860) 4515860..4517770 + 1911 WP_004152270.1 PRD domain-containing protein -
N5936_RS22010 (4517848) 4517848..4518090 + 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5936_RS22015 (4518080) 4518080..4518364 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5936_RS22020 (4518368) 4518368..4518832 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N5936_RS22025 (4519074) 4519074..4521212 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N5936_RS22030 (4521569) 4521569..4522312 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N5936_RS22035 (4522315) 4522315..4522488 - 174 WP_032414379.1 hypothetical protein -
N5936_RS22040 (4522573) 4522573..4522881 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T258892 WP_004178374.1 NZ_CP104659:4518080-4518364 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT258892 WP_032434351.1 NZ_CP104659:4517848-4518090 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References