Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 4356206..4357887 | Replicon | chromosome |
Accession | NZ_CP104659 | ||
Organism | Klebsiella pneumoniae strain 2020CK-00096 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | W8V1Q6 |
Locus tag | N5936_RS21210 | Protein ID | WP_002885155.1 |
Coordinates | 4356970..4357887 (+) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | A6TH05 |
Locus tag | N5936_RS21205 | Protein ID | WP_004177809.1 |
Coordinates | 4356206..4356964 (+) | Length | 253 a.a. |
Genomic Context
Location: 4355392..4356120 (729 bp)
Type: Others
Protein ID: WP_004177810.1
Type: Others
Protein ID: WP_004177810.1
Location: 4356206..4356964 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 4356970..4357887 (918 bp)
Type: Toxin
Protein ID: WP_002885155.1
Type: Toxin
Protein ID: WP_002885155.1
Location: 4352056..4352742 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Type: Others
Protein ID: WP_004151733.1
Location: 4352972..4355119 (2148 bp)
Type: Others
Protein ID: WP_077598921.1
Type: Others
Protein ID: WP_077598921.1
Location: 4358012..4359019 (1008 bp)
Type: Others
Protein ID: WP_004177805.1
Type: Others
Protein ID: WP_004177805.1
Location: 4359094..4360035 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Type: Others
Protein ID: WP_002885156.1
Location: 4360066..4361064 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Type: Others
Protein ID: WP_002885172.1
Location: 4361061..4362581 (1521 bp)
Type: Others
Protein ID: WP_002885173.1
Type: Others
Protein ID: WP_002885173.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5936_RS21190 (4352056) | 4352056..4352742 | - | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
N5936_RS21195 (4352972) | 4352972..4355119 | - | 2148 | WP_077598921.1 | formate dehydrogenase subunit alpha | - |
N5936_RS21200 (4355392) | 4355392..4356120 | + | 729 | WP_004177810.1 | response regulator transcription factor | - |
N5936_RS21205 (4356206) | 4356206..4356964 | + | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
N5936_RS21210 (4356970) | 4356970..4357887 | + | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
N5936_RS21215 (4358012) | 4358012..4359019 | - | 1008 | WP_004177805.1 | carbohydrate kinase family protein | - |
N5936_RS21220 (4359094) | 4359094..4360035 | - | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
N5936_RS21225 (4360066) | 4360066..4361064 | - | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
N5936_RS21230 (4361061) | 4361061..4362581 | - | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T258891 WP_002885155.1 NZ_CP104659:4356970-4357887 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT258891 WP_004177809.1 NZ_CP104659:4356206-4356964 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GH11 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A6TH05 |