Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4356206..4357887 Replicon chromosome
Accession NZ_CP104659
Organism Klebsiella pneumoniae strain 2020CK-00096

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag N5936_RS21210 Protein ID WP_002885155.1
Coordinates 4356970..4357887 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag N5936_RS21205 Protein ID WP_004177809.1
Coordinates 4356206..4356964 (+) Length 253 a.a.

Genomic Context


N5936_RS21200N5936_RS21205N5936_RS21210N5936_RS21190N5936_RS21195N5936_RS21215N5936_RS21220N5936_RS21225N5936_RS21230
Location: 4355392..4356120 (729 bp)
Type: Others
Protein ID: WP_004177810.1
Location: 4356206..4356964 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 4356970..4357887 (918 bp)
Type: Toxin
Protein ID: WP_002885155.1
Location: 4352056..4352742 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Location: 4352972..4355119 (2148 bp)
Type: Others
Protein ID: WP_077598921.1
Location: 4358012..4359019 (1008 bp)
Type: Others
Protein ID: WP_004177805.1
Location: 4359094..4360035 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Location: 4360066..4361064 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Location: 4361061..4362581 (1521 bp)
Type: Others
Protein ID: WP_002885173.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N5936_RS21190 (4352056)4352056..4352742-687WP_004151733.1tetratricopeptide repeat protein-
N5936_RS21195 (4352972)4352972..4355119-2148WP_077598921.1formate dehydrogenase subunit alpha-
N5936_RS21200 (4355392)4355392..4356120+729WP_004177810.1response regulator transcription factor-
N5936_RS21205 (4356206)4356206..4356964+759WP_004177809.1type IV toxin-antitoxin system AbiEi family antitoxinAntitoxin
N5936_RS21210 (4356970)4356970..4357887+918WP_002885155.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
N5936_RS21215 (4358012)4358012..4359019-1008WP_004177805.1carbohydrate kinase family protein-
N5936_RS21220 (4359094)4359094..4360035-942WP_002885156.1ABC transporter substrate-binding protein-
N5936_RS21225 (4360066)4360066..4361064-999WP_002885172.1ribose ABC transporter permease-
N5936_RS21230 (4361061)4361061..4362581-1521WP_002885173.1sugar ABC transporter ATP-binding protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T258891 WP_002885155.1 NZ_CP104659:4356970-4357887 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT258891 WP_004177809.1 NZ_CP104659:4356206-4356964 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GH11


Antitoxin

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Source
ID
Structure
AlphaFold DBA6TH05

References