Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4356206..4357887 Replicon chromosome
Accession NZ_CP104659
Organism Klebsiella pneumoniae strain 2020CK-00096

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag N5936_RS21210 Protein ID WP_002885155.1
Coordinates 4356970..4357887 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag N5936_RS21205 Protein ID WP_004177809.1
Coordinates 4356206..4356964 (+) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5936_RS21190 (4352056) 4352056..4352742 - 687 WP_004151733.1 tetratricopeptide repeat protein -
N5936_RS21195 (4352972) 4352972..4355119 - 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
N5936_RS21200 (4355392) 4355392..4356120 + 729 WP_004177810.1 response regulator transcription factor -
N5936_RS21205 (4356206) 4356206..4356964 + 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
N5936_RS21210 (4356970) 4356970..4357887 + 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N5936_RS21215 (4358012) 4358012..4359019 - 1008 WP_004177805.1 carbohydrate kinase family protein -
N5936_RS21220 (4359094) 4359094..4360035 - 942 WP_002885156.1 ABC transporter substrate-binding protein -
N5936_RS21225 (4360066) 4360066..4361064 - 999 WP_002885172.1 ribose ABC transporter permease -
N5936_RS21230 (4361061) 4361061..4362581 - 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T258891 WP_002885155.1 NZ_CP104659:4356970-4357887 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT258891 WP_004177809.1 NZ_CP104659:4356206-4356964 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References