Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3157028..3157685 Replicon chromosome
Accession NZ_CP104659
Organism Klebsiella pneumoniae strain 2020CK-00096

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N5936_RS15375 Protein ID WP_002916310.1
Coordinates 3157028..3157438 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N5936_RS15380 Protein ID WP_002916312.1
Coordinates 3157419..3157685 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5936_RS15355 (3153028) 3153028..3154761 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
N5936_RS15360 (3154767) 3154767..3155480 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5936_RS15365 (3155503) 3155503..3156399 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N5936_RS15370 (3156500) 3156500..3157021 + 522 WP_002916308.1 flavodoxin FldB -
N5936_RS15375 (3157028) 3157028..3157438 - 411 WP_002916310.1 protein YgfX Toxin
N5936_RS15380 (3157419) 3157419..3157685 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N5936_RS15385 (3157931) 3157931..3158914 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
N5936_RS15390 (3159013) 3159013..3159672 - 660 WP_004174454.1 hemolysin III family protein -
N5936_RS15395 (3159836) 3159836..3160147 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
N5936_RS15400 (3160197) 3160197..3160925 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N5936_RS15405 (3161044) 3161044..3162477 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T258887 WP_002916310.1 NZ_CP104659:c3157438-3157028 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT258887 WP_002916312.1 NZ_CP104659:c3157685-3157419 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References