Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1669919..1671507 Replicon chromosome
Accession NZ_CP104659
Organism Klebsiella pneumoniae strain 2020CK-00096

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag N5936_RS08165 Protein ID WP_004892016.1
Coordinates 1669919..1671241 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5936_RS08170 Protein ID WP_004176198.1
Coordinates 1671241..1671507 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5936_RS08150 (1664975) 1664975..1667476 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
N5936_RS08155 (1667464) 1667464..1668468 + 1005 WP_032435338.1 fimbrial protein -
N5936_RS08160 (1668610) 1668610..1669902 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N5936_RS08165 (1669919) 1669919..1671241 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
N5936_RS08170 (1671241) 1671241..1671507 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5936_RS08175 (1671894) 1671894..1672220 - 327 WP_004184023.1 hydroxyisourate hydrolase -
N5936_RS08180 (1672217) 1672217..1672717 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N5936_RS08185 (1672695) 1672695..1674074 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
N5936_RS08190 (1674420) 1674420..1675574 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N5936_RS08195 (1675555) 1675555..1676478 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-402)

Antitoxin

(13-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T258886 WP_004892016.1 NZ_CP104659:c1671241-1669919 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT258886 WP_004176198.1 NZ_CP104659:c1671507-1671241 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References