Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 1669919..1671507 | Replicon | chromosome |
Accession | NZ_CP104659 | ||
Organism | Klebsiella pneumoniae strain 2020CK-00096 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A9J6RYF8 |
Locus tag | N5936_RS08165 | Protein ID | WP_004892016.1 |
Coordinates | 1669919..1671241 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | N5936_RS08170 | Protein ID | WP_004176198.1 |
Coordinates | 1671241..1671507 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5936_RS08150 (1664975) | 1664975..1667476 | + | 2502 | WP_032435337.1 | fimbria/pilus outer membrane usher protein | - |
N5936_RS08155 (1667464) | 1667464..1668468 | + | 1005 | WP_032435338.1 | fimbrial protein | - |
N5936_RS08160 (1668610) | 1668610..1669902 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
N5936_RS08165 (1669919) | 1669919..1671241 | - | 1323 | WP_004892016.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
N5936_RS08170 (1671241) | 1671241..1671507 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
N5936_RS08175 (1671894) | 1671894..1672220 | - | 327 | WP_004184023.1 | hydroxyisourate hydrolase | - |
N5936_RS08180 (1672217) | 1672217..1672717 | - | 501 | WP_032435339.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
N5936_RS08185 (1672695) | 1672695..1674074 | - | 1380 | WP_004184021.1 | nucleobase:cation symporter-2 family protein | - |
N5936_RS08190 (1674420) | 1674420..1675574 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
N5936_RS08195 (1675555) | 1675555..1676478 | - | 924 | WP_008804925.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49141.44 Da Isoelectric Point: 7.5357
>T258886 WP_004892016.1 NZ_CP104659:c1671241-1669919 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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