Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 5283884..5284589 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag N5913_RS26455 Protein ID WP_000539519.1
Coordinates 5284203..5284589 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N5913_RS26450 Protein ID WP_001280945.1
Coordinates 5283884..5284213 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS26435 (5279041) 5279041..5279952 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
N5913_RS26440 (5280130) 5280130..5282478 + 2349 WP_000950320.1 EAL domain-containing protein -
N5913_RS26445 (5282486) 5282486..5283814 + 1329 WP_000086905.1 GGDEF domain-containing protein -
N5913_RS26450 (5283884) 5283884..5284213 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N5913_RS26455 (5284203) 5284203..5284589 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5913_RS26460 (5284815) 5284815..5286140 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N5913_RS26465 (5286353) 5286353..5286736 + 384 WP_000497137.1 biofilm formation regulator BssR -
N5913_RS26470 (5286847) 5286847..5287962 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
N5913_RS26475 (5287959) 5287959..5288585 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T258871 WP_000539519.1 NZ_CP104649:c5284589-5284203 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT258871 WP_001280945.1 NZ_CP104649:c5284213-5283884 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References