Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4829194..4829812 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5913_RS24365 Protein ID WP_001291435.1
Coordinates 4829194..4829412 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5913_RS24370 Protein ID WP_000344800.1
Coordinates 4829438..4829812 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS24330 (4824481) 4824481..4825053 + 573 WP_000779831.1 YbaY family lipoprotein -
N5913_RS24335 (4825086) 4825086..4825397 - 312 WP_000409911.1 MGMT family protein -
N5913_RS24345 (4825776) 4825776..4826129 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N5913_RS24350 (4826171) 4826171..4827721 - 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5913_RS24355 (4827885) 4827885..4828355 - 471 WP_000136192.1 YlaC family protein -
N5913_RS24360 (4828471) 4828471..4829022 - 552 WP_000102553.1 maltose O-acetyltransferase -
N5913_RS24365 (4829194) 4829194..4829412 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N5913_RS24370 (4829438) 4829438..4829812 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5913_RS24375 (4830358) 4830358..4833507 - 3150 WP_001132452.1 efflux RND transporter permease AcrB -
N5913_RS24380 (4833530) 4833530..4834723 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258870 WP_001291435.1 NZ_CP104649:c4829412-4829194 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258870 WP_000344800.1 NZ_CP104649:c4829812-4829438 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References