25887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 756428..756968 Replicon chromosome
Accession NC_016804
Organism Mycobacterium bovis BCG str. Mexico

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag BCGMEX_RS03465 Protein ID WP_003403376.1
Coordinates 756428..756736 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag BCGMEX_RS03470 Protein ID WP_003403381.1
Coordinates 756723..756968 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCGMEX_RS03440 751743..753248 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
BCGMEX_RS03445 753329..754339 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
BCGMEX_RS03450 754727..755110 - 384 WP_003403365.1 ribonuclease VapC6 -
BCGMEX_RS03455 755205..755360 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
BCGMEX_RS03460 755436..756152 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
BCGMEX_RS03465 756428..756736 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BCGMEX_RS03470 756723..756968 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
BCGMEX_RS03475 757078..757515 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
BCGMEX_RS03480 757512..757766 - 255 WP_003911263.1 antitoxin VapB7 -
BCGMEX_RS03485 757880..760243 + 2364 WP_003403397.1 arylsulfatase AtsD -
BCGMEX_RS03490 760306..760632 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BCGMEX_RS03495 760544..760882 + 339 WP_003403405.1 PIN domain-containing protein -
BCGMEX_RS03500 760879..761052 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T25887 WP_003403376.1 NC_016804:c756736-756428 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T25887 NC_016804:c756736-756428 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT25887 WP_003403381.1 NC_016804:c756968-756723 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT25887 NC_016804:c756968-756723 [Mycobacterium tuberculosis variant bovis BCG str. Mexico]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References