Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4084925..4085520 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N5913_RS20990 Protein ID WP_000239579.1
Coordinates 4085170..4085520 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag N5913_RS20985 Protein ID WP_001223210.1
Coordinates 4084925..4085176 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS20975 (4080590) 4080590..4084369 + 3780 WP_000060930.1 autotransporter assembly complex protein TamB -
N5913_RS20980 (4084372) 4084372..4084713 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N5913_RS20985 (4084925) 4084925..4085176 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N5913_RS20990 (4085170) 4085170..4085520 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N5913_RS20995 (4085600) 4085600..4086130 - 531 WP_000055075.1 inorganic diphosphatase -
N5913_RS21000 (4086440) 4086440..4087396 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N5913_RS21005 (4087536) 4087536..4089038 + 1503 Protein_4095 sugar ABC transporter ATP-binding protein -
N5913_RS21010 (4089052) 4089052..4090074 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T258863 WP_000239579.1 NZ_CP104649:4085170-4085520 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT258863 WP_001223210.1 NZ_CP104649:4084925-4085176 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References