Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3125909..3126709 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name ataT Uniprot ID A0A891SNC1
Locus tag N5913_RS16410 Protein ID WP_000342448.1
Coordinates 3125909..3126436 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag N5913_RS16415 Protein ID WP_001277108.1
Coordinates 3126443..3126709 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS16385 (3120984) 3120984..3121751 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
N5913_RS16390 (3121748) 3121748..3123025 - 1278 WP_000803797.1 branched chain amino acid ABC transporter permease LivM -
N5913_RS16395 (3123022) 3123022..3123948 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
N5913_RS16400 (3123996) 3123996..3125105 - 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
N5913_RS16405 (3125529) 3125529..3125912 + 384 WP_000778769.1 aspartate 1-decarboxylase autocleavage activator PanM -
N5913_RS16410 (3125909) 3125909..3126436 - 528 WP_000342448.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
N5913_RS16415 (3126443) 3126443..3126709 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
N5913_RS16420 (3126859) 3126859..3127962 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
N5913_RS16425 (3128233) 3128233..3129087 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
N5913_RS16430 (3129332) 3129332..3130390 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
N5913_RS16435 (3130383) 3130383..3131051 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19692.68 Da        Isoelectric Point: 7.3232

>T258858 WP_000342448.1 NZ_CP104649:c3126436-3125909 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT258858 WP_001277108.1 NZ_CP104649:c3126709-3126443 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6GTS

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References