Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3077054..3077808 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag N5913_RS16200 Protein ID WP_001301452.1
Coordinates 3077323..3077808 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag N5913_RS16195 Protein ID WP_000801912.1
Coordinates 3077054..3077332 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS16190 (3074282) 3074282..3076987 + 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -
N5913_RS16195 (3077054) 3077054..3077332 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
N5913_RS16200 (3077323) 3077323..3077808 + 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
N5913_RS16205 (3077858) 3077858..3078886 - 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
N5913_RS16210 (3078890) 3078890..3080116 - 1227 WP_001105473.1 RNA-splicing ligase RtcB -
N5913_RS16215 (3080304) 3080304..3081902 + 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
N5913_RS16220 (3081884) 3081884..3082642 - 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T258857 WP_001301452.1 NZ_CP104649:3077323-3077808 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT258857 WP_000801912.1 NZ_CP104649:3077054-3077332 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References