Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 685980..686618 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5913_RS03735 Protein ID WP_000813794.1
Coordinates 685980..686156 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5913_RS03740 Protein ID WP_001270286.1
Coordinates 686202..686618 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS03715 (681601) 681601..682774 - 1174 Protein_733 BenE family transporter YdcO -
N5913_RS03720 (682866) 682866..683402 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
N5913_RS03725 (683475) 683475..685436 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5913_RS03730 (685528) 685528..685758 - 231 WP_000494244.1 YncJ family protein -
N5913_RS03735 (685980) 685980..686156 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5913_RS03740 (686202) 686202..686618 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5913_RS03745 (686697) 686697..688103 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
N5913_RS03750 (688348) 688348..689493 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
N5913_RS03755 (689511) 689511..690524 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
N5913_RS03760 (690525) 690525..691466 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258845 WP_000813794.1 NZ_CP104649:685980-686156 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258845 WP_001270286.1 NZ_CP104649:686202-686618 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References