Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 5057206..5057677 Replicon chromosome
Accession NZ_CP104647
Organism Escherichia coli strain PNUSAE008406

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag N5921_RS25250 Protein ID WP_001303511.1
Coordinates 5057399..5057677 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag N5921_RS25245 Protein ID WP_001302048.1
Coordinates 5057206..5057397 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5921_RS25205 (5052414) 5052414..5052997 - 584 Protein_4912 DUF551 domain-containing protein -
N5921_RS25210 (5053054) 5053054..5053449 - 396 WP_001118159.1 DUF977 family protein -
N5921_RS25215 (5053465) 5053465..5054234 - 770 Protein_4914 DUF1627 domain-containing protein -
N5921_RS25220 (5054260) 5054260..5055000 - 741 WP_000788938.1 ATP-binding protein -
N5921_RS25225 (5055007) 5055007..5055969 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
N5921_RS25230 (5055992) 5055992..5056417 - 426 WP_000693943.1 toxin YdaT family protein -
N5921_RS25235 (5056414) 5056414..5056716 - 303 WP_000172738.1 transcriptional regulator -
N5921_RS25240 (5056814) 5056814..5057185 + 372 WP_001169686.1 hypothetical protein -
N5921_RS25245 (5057206) 5057206..5057397 + 192 WP_001302048.1 hypothetical protein Antitoxin
N5921_RS25250 (5057399) 5057399..5057677 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5921_RS25255 (5058030) 5058030..5058329 + 300 WP_001240334.1 hypothetical protein -
N5921_RS25260 (5058401) 5058401..5058619 + 219 WP_001171930.1 protein YdfC -
N5921_RS25265 (5059188) 5059188..5059377 + 190 Protein_4924 cell division inhibition protein DicB -
N5921_RS25270 (5059374) 5059374..5059565 + 192 WP_001090200.1 DUF1482 family protein -
N5921_RS25275 (5059658) 5059658..5060743 + 1086 Protein_4926 exonuclease -
N5921_RS25280 (5060794) 5060794..5062007 + 1214 WP_261589719.1 IS3-like element IS1203 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 4974807..5073871 99064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T258837 WP_001303511.1 NZ_CP104647:5057399-5057677 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT258837 WP_001302048.1 NZ_CP104647:5057206-5057397 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References