Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4842955..4843593 Replicon chromosome
Accession NZ_CP104647
Organism Escherichia coli strain PNUSAE008406

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5921_RS24090 Protein ID WP_000813794.1
Coordinates 4842955..4843131 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5921_RS24095 Protein ID WP_001270286.1
Coordinates 4843177..4843593 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5921_RS24070 (4838576) 4838576..4839749 - 1174 Protein_4690 BenE family transporter YdcO -
N5921_RS24075 (4839841) 4839841..4840377 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
N5921_RS24080 (4840450) 4840450..4842411 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5921_RS24085 (4842503) 4842503..4842733 - 231 WP_000494244.1 YncJ family protein -
N5921_RS24090 (4842955) 4842955..4843131 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5921_RS24095 (4843177) 4843177..4843593 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5921_RS24100 (4843672) 4843672..4845078 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
N5921_RS24105 (4845323) 4845323..4846468 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
N5921_RS24110 (4846486) 4846486..4847499 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
N5921_RS24115 (4847500) 4847500..4848441 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258835 WP_000813794.1 NZ_CP104647:4842955-4843131 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258835 WP_001270286.1 NZ_CP104647:4843177-4843593 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References