Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3954466..3955171 Replicon chromosome
Accession NZ_CP104647
Organism Escherichia coli strain PNUSAE008406

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag N5921_RS19350 Protein ID WP_000539519.1
Coordinates 3954785..3955171 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N5921_RS19345 Protein ID WP_001280945.1
Coordinates 3954466..3954795 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5921_RS19330 (3949623) 3949623..3950534 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
N5921_RS19335 (3950712) 3950712..3953060 + 2349 WP_000950320.1 EAL domain-containing protein -
N5921_RS19340 (3953068) 3953068..3954396 + 1329 WP_000086905.1 GGDEF domain-containing protein -
N5921_RS19345 (3954466) 3954466..3954795 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N5921_RS19350 (3954785) 3954785..3955171 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5921_RS19355 (3955397) 3955397..3956722 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N5921_RS19360 (3956935) 3956935..3957318 + 384 WP_000497137.1 biofilm formation regulator BssR -
N5921_RS19365 (3957429) 3957429..3958544 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
N5921_RS19370 (3958541) 3958541..3959167 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T258830 WP_000539519.1 NZ_CP104647:c3955171-3954785 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT258830 WP_001280945.1 NZ_CP104647:c3954795-3954466 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References