Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1839071..1839702 Replicon chromosome
Accession NZ_CP104647
Organism Escherichia coli strain PNUSAE008406

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag N5921_RS09535 Protein ID WP_001259385.1
Coordinates 1839427..1839702 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N5921_RS09530 Protein ID WP_000593555.1
Coordinates 1839071..1839430 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5921_RS09500 (1834183) 1834183..1834656 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
N5921_RS09505 (1834653) 1834653..1834934 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
N5921_RS09510 (1835011) 1835011..1836369 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
N5921_RS09515 (1836362) 1836362..1837870 + 1509 WP_001301773.1 FGGY-family carbohydrate kinase -
N5921_RS09520 (1837860) 1837860..1838129 + 270 WP_000933060.1 HPr family phosphocarrier protein -
N5921_RS09525 (1838161) 1838161..1839021 + 861 WP_001131788.1 class II aldolase -
N5921_RS09530 (1839071) 1839071..1839430 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5921_RS09535 (1839427) 1839427..1839702 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
N5921_RS09540 (1839775) 1839775..1840899 - 1125 WP_001301659.1 ABC transporter permease -
N5921_RS09545 (1840899) 1840899..1843634 - 2736 WP_000149110.1 ribosome-associated ATPase/putative transporter RbbA -
N5921_RS09550 (1843631) 1843631..1844698 - 1068 WP_000361458.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T258818 WP_001259385.1 NZ_CP104647:c1839702-1839427 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT258818 WP_000593555.1 NZ_CP104647:c1839430-1839071 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References