Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1796471..1797271 Replicon chromosome
Accession NZ_CP104647
Organism Escherichia coli strain PNUSAE008406

Toxin (Protein)


Gene name ataT Uniprot ID A0A891SNC1
Locus tag N5921_RS09285 Protein ID WP_000342448.1
Coordinates 1796471..1796998 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag N5921_RS09290 Protein ID WP_001277108.1
Coordinates 1797005..1797271 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5921_RS09260 (1791546) 1791546..1792313 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
N5921_RS09265 (1792310) 1792310..1793587 - 1278 WP_000803797.1 branched chain amino acid ABC transporter permease LivM -
N5921_RS09270 (1793584) 1793584..1794510 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
N5921_RS09275 (1794558) 1794558..1795667 - 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
N5921_RS09280 (1796091) 1796091..1796474 + 384 WP_000778769.1 aspartate 1-decarboxylase autocleavage activator PanM -
N5921_RS09285 (1796471) 1796471..1796998 - 528 WP_000342448.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
N5921_RS09290 (1797005) 1797005..1797271 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
N5921_RS09295 (1797421) 1797421..1798524 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
N5921_RS09300 (1798795) 1798795..1799649 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
N5921_RS09305 (1799894) 1799894..1800952 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
N5921_RS09310 (1800945) 1800945..1801613 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19692.68 Da        Isoelectric Point: 7.3232

>T258817 WP_000342448.1 NZ_CP104647:c1796998-1796471 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT258817 WP_001277108.1 NZ_CP104647:c1797271-1797005 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6GTS

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References