Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4825559..4826197 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N5932_RS23940 Protein ID WP_000813794.1
Coordinates 4825559..4825735 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5932_RS23945 Protein ID WP_001270286.1
Coordinates 4825781..4826197 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS23920 (4821180) 4821180..4822353 - 1174 Protein_4658 BenE family transporter YdcO -
N5932_RS23925 (4822445) 4822445..4822981 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
N5932_RS23930 (4823054) 4823054..4825015 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N5932_RS23935 (4825107) 4825107..4825337 - 231 WP_000494244.1 YncJ family protein -
N5932_RS23940 (4825559) 4825559..4825735 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N5932_RS23945 (4825781) 4825781..4826197 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N5932_RS23950 (4826276) 4826276..4827682 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
N5932_RS23955 (4827927) 4827927..4829072 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
N5932_RS23960 (4829090) 4829090..4830103 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
N5932_RS23965 (4830104) 4830104..4831045 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T258803 WP_000813794.1 NZ_CP104645:4825559-4825735 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT258803 WP_001270286.1 NZ_CP104645:4825781-4826197 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References