Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3483922..3484540 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5932_RS17120 Protein ID WP_001291435.1
Coordinates 3483922..3484140 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5932_RS17125 Protein ID WP_000344800.1
Coordinates 3484166..3484540 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS17085 (3479209) 3479209..3479781 + 573 WP_000779831.1 YbaY family lipoprotein -
N5932_RS17090 (3479814) 3479814..3480125 - 312 WP_000409911.1 MGMT family protein -
N5932_RS17100 (3480504) 3480504..3480857 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N5932_RS17105 (3480899) 3480899..3482449 - 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5932_RS17110 (3482613) 3482613..3483083 - 471 WP_000136192.1 YlaC family protein -
N5932_RS17115 (3483199) 3483199..3483750 - 552 WP_000102553.1 maltose O-acetyltransferase -
N5932_RS17120 (3483922) 3483922..3484140 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N5932_RS17125 (3484166) 3484166..3484540 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5932_RS17130 (3485086) 3485086..3488235 - 3150 WP_001132452.1 efflux RND transporter permease AcrB -
N5932_RS17135 (3488258) 3488258..3489451 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258797 WP_001291435.1 NZ_CP104645:c3484140-3483922 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258797 WP_000344800.1 NZ_CP104645:c3484540-3484166 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References