Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2988707..2989257 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag N5932_RS14810 Protein ID WP_001160975.1
Coordinates 2988943..2989257 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag N5932_RS14805 Protein ID WP_000125566.1
Coordinates 2988707..2988940 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS14780 (2983781) 2983781..2984068 + 288 WP_000203741.1 ferredoxin-like protein FixX -
N5932_RS14785 (2984126) 2984126..2985457 + 1332 WP_001183177.1 MFS transporter -
N5932_RS14790 (2985565) 2985565..2986095 + 531 WP_000600700.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
N5932_RS14795 (2986088) 2986088..2987950 + 1863 WP_000377184.1 glutathione-regulated potassium-efflux system protein KefC -
N5932_RS14800 (2988142) 2988142..2988621 + 480 WP_000624372.1 type 3 dihydrofolate reductase -
N5932_RS14805 (2988707) 2988707..2988940 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N5932_RS14810 (2988943) 2988943..2989257 + 315 WP_001160975.1 CcdB family protein Toxin
N5932_RS14815 (2989254) 2989254..2990102 - 849 WP_000257187.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
N5932_RS14820 (2990109) 2990109..2990486 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
N5932_RS14825 (2990489) 2990489..2991310 - 822 WP_001065380.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
N5932_RS14830 (2991307) 2991307..2992296 - 990 WP_000241259.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
N5932_RS14835 (2992296) 2992296..2993582 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T258795 WP_001160975.1 NZ_CP104645:2988943-2989257 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT258795 WP_000125566.1 NZ_CP104645:2988707-2988940 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References