258790

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2739631..2740226 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N5932_RS13755 Protein ID WP_000239579.1
Coordinates 2739876..2740226 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag N5932_RS13750 Protein ID WP_001223210.1
Coordinates 2739631..2739882 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS13740 (2735296) 2735296..2739075 + 3780 WP_000060930.1 autotransporter assembly complex protein TamB -
N5932_RS13745 (2739078) 2739078..2739419 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N5932_RS13750 (2739631) 2739631..2739882 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N5932_RS13755 (2739876) 2739876..2740226 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N5932_RS13760 (2740306) 2740306..2740836 - 531 WP_000055075.1 inorganic diphosphatase -
N5932_RS13765 (2741146) 2741146..2742102 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N5932_RS13770 (2742242) 2742242..2743744 + 1503 Protein_2666 sugar ABC transporter ATP-binding protein -
N5932_RS13775 (2743758) 2743758..2744780 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T258790 WP_000239579.1 NZ_CP104645:2739876-2740226 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT258790 WP_001223210.1 NZ_CP104645:2739631-2739882 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References