Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1731549..1732303 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag N5932_RS08970 Protein ID WP_001301452.1
Coordinates 1731818..1732303 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag N5932_RS08965 Protein ID WP_000801912.1
Coordinates 1731549..1731827 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS08960 (1728777) 1728777..1731482 + 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -
N5932_RS08965 (1731549) 1731549..1731827 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
N5932_RS08970 (1731818) 1731818..1732303 + 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
N5932_RS08975 (1732353) 1732353..1733381 - 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
N5932_RS08980 (1733385) 1733385..1734611 - 1227 WP_001105473.1 RNA-splicing ligase RtcB -
N5932_RS08985 (1734799) 1734799..1736397 + 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
N5932_RS08990 (1736379) 1736379..1737137 - 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T258784 WP_001301452.1 NZ_CP104645:1731818-1732303 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT258784 WP_000801912.1 NZ_CP104645:1731549-1731827 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References