258778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4570582..4571363 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag N5930_RS22410 Protein ID WP_000626100.1
Coordinates 4570582..4571073 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag N5930_RS22415 Protein ID WP_001110452.1
Coordinates 4571070..4571363 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS22375 (4566042) 4566042..4566389 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
N5930_RS22380 (4566365) 4566365..4568068 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
N5930_RS22385 (4568105) 4568105..4568680 + 576 WP_001188509.1 transcriptional regulator -
N5930_RS22395 (4568951) 4568951..4569025 - 75 Protein_4356 helix-turn-helix domain-containing protein -
N5930_RS22400 (4569405) 4569405..4569482 + 78 Protein_4357 porin family protein -
N5930_RS22405 (4569582) 4569582..4570334 + 753 WP_000842433.1 non-specific acid phosphatase -
N5930_RS22410 (4570582) 4570582..4571073 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
N5930_RS22415 (4571070) 4571070..4571363 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
N5930_RS22420 (4571680) 4571680..4571901 + 222 WP_001576552.1 hypothetical protein -
N5930_RS22425 (4572167) 4572167..4573042 + 876 WP_000921676.1 AraC family transcriptional regulator -
N5930_RS22430 (4573039) 4573039..4573326 + 288 WP_001541332.1 transcriptional regulator RtsB -
N5930_RS22435 (4573319) 4573319..4573627 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
N5930_RS22440 (4573626) 4573626..4573874 + 249 Protein_4365 Ig-like domain-containing protein -
N5930_RS22445 (4573986) 4573986..4574117 + 132 Protein_4366 hypothetical protein -
N5930_RS22450 (4574411) 4574411..4575316 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T258778 WP_000626100.1 NZ_CP104643:c4571073-4570582 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT258778 WP_001110452.1 NZ_CP104643:c4571363-4571070 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References