258777

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4463686..4464202 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag N5930_RS21835 Protein ID WP_000220582.1
Coordinates 4463686..4463970 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N5930_RS21840 Protein ID WP_000212724.1
Coordinates 4463960..4464202 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS21820 (4458897) 4458897..4460549 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
N5930_RS21825 (4460958) 4460958..4463096 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
N5930_RS21830 (4463218) 4463218..4463682 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N5930_RS21835 (4463686) 4463686..4463970 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5930_RS21840 (4463960) 4463960..4464202 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5930_RS21845 (4464280) 4464280..4466193 - 1914 WP_001212142.1 BglG family transcription antiterminator -
N5930_RS21850 (4466210) 4466210..4466950 - 741 WP_000779259.1 KDGP aldolase family protein -
N5930_RS21855 (4466947) 4466947..4468065 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N5930_RS21860 (4468049) 4468049..4469182 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T258777 WP_000220582.1 NZ_CP104643:c4463970-4463686 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258777 WP_000212724.1 NZ_CP104643:c4464202-4463960 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References