258776

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4422561..4423111 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag N5930_RS21625 Protein ID WP_001199743.1
Coordinates 4422561..4422869 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag N5930_RS21630 Protein ID WP_001118105.1
Coordinates 4422872..4423111 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS21605 (4419135) 4419135..4419875 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
N5930_RS21610 (4419997) 4419997..4420527 - 531 WP_001708209.1 SEF14 fimbria major subunit SefA -
N5930_RS21615 (4420850) 4420850..4421983 + 1134 Protein_4205 IS3 family transposase -
N5930_RS21620 (4422015) 4422015..4422155 - 141 Protein_4206 Arm DNA-binding domain-containing protein -
N5930_RS21625 (4422561) 4422561..4422869 - 309 WP_001199743.1 CcdB family protein Toxin
N5930_RS21630 (4422872) 4422872..4423111 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N5930_RS21635 (4423220) 4423220..4423468 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
N5930_RS21640 (4423545) 4423545..4424090 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
N5930_RS21650 (4424847) 4424847..4425866 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
N5930_RS21655 (4425894) 4425894..4426424 - 531 WP_000896758.1 gluconokinase -
N5930_RS21660 (4426641) 4426641..4427672 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4420942..4424045 3103
- inside Genomic island - - 4403818..4423468 19650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T258776 WP_001199743.1 NZ_CP104643:c4422869-4422561 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT258776 WP_001118105.1 NZ_CP104643:c4423111-4422872 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References