258775

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4372286..4372862 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag N5930_RS21390 Protein ID WP_001131963.1
Coordinates 4372575..4372862 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag N5930_RS21385 Protein ID WP_000063142.1
Coordinates 4372286..4372588 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS21370 (4368796) 4368796..4370946 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
N5930_RS21375 (4371041) 4371041..4371244 + 204 WP_000460616.1 YbdD/YjiX family protein -
N5930_RS21380 (4371255) 4371255..4372211 + 957 WP_000187843.1 GTPase -
N5930_RS21385 (4372286) 4372286..4372588 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
N5930_RS21390 (4372575) 4372575..4372862 - 288 WP_001131963.1 BrnT family toxin Toxin
N5930_RS21395 (4373293) 4373293..4375134 + 1842 WP_000974637.1 nuclease-related domain-containing DEAD/DEAH box helicase -
N5930_RS21400 (4375747) 4375747..4376322 + 576 WP_000593784.1 restriction endonuclease subunit S -
N5930_RS21405 (4376327) 4376327..4377580 + 1254 WP_001206755.1 N-6 DNA methylase -
N5930_RS21410 (4377612) 4377612..4377746 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T258775 WP_001131963.1 NZ_CP104643:c4372862-4372575 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT258775 WP_000063142.1 NZ_CP104643:c4372588-4372286 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6PB01

References