258772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3757497..3758117 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N5930_RS18435 Protein ID WP_001280991.1
Coordinates 3757899..3758117 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N5930_RS18430 Protein ID WP_000344807.1
Coordinates 3757497..3757871 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS18420 (3752636) 3752636..3753829 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5930_RS18425 (3753852) 3753852..3757001 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N5930_RS18430 (3757497) 3757497..3757871 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N5930_RS18435 (3757899) 3757899..3758117 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N5930_RS18440 (3758296) 3758296..3758847 + 552 WP_001278793.1 maltose O-acetyltransferase -
N5930_RS18445 (3758965) 3758965..3759435 + 471 WP_000136183.1 YlaC family protein -
N5930_RS18450 (3759491) 3759491..3759631 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N5930_RS18455 (3759637) 3759637..3759897 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N5930_RS18460 (3760122) 3760122..3761672 + 1551 WP_000213140.1 EAL domain-containing protein -
N5930_RS18470 (3761903) 3761903..3762292 + 390 WP_000961287.1 MGMT family protein -
N5930_RS18475 (3762325) 3762325..3762894 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258772 WP_001280991.1 NZ_CP104643:3757899-3758117 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258772 WP_000344807.1 NZ_CP104643:3757497-3757871 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References