258761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 552134..552894 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag N5930_RS02615 Protein ID WP_000533912.1
Coordinates 552409..552894 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag N5930_RS02610 Protein ID WP_000965886.1
Coordinates 552134..552421 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS02590 (547539) 547539..548450 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
N5930_RS02595 (548460) 548460..550529 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
N5930_RS02600 (550919) 550919..551317 + 399 Protein_491 IS3 family transposase -
N5930_RS02605 (551489) 551489..551956 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
N5930_RS02610 (552134) 552134..552421 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
N5930_RS02615 (552409) 552409..552894 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
N5930_RS02620 (553265) 553265..553804 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
N5930_RS02625 (553978) 553978..554190 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
N5930_RS02630 (554478) 554478..554768 - 291 WP_000455790.1 HTH-type transcriptional regulator -
N5930_RS02635 (555207) 555207..555917 + 711 WP_000190524.1 DUF3053 domain-containing protein -
N5930_RS02640 (555967) 555967..556941 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
N5930_RS02645 (557160) 557160..557822 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T258761 WP_000533912.1 NZ_CP104643:552409-552894 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT258761 WP_000965886.1 NZ_CP104643:552134-552421 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References