Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4218641..4219422 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag N5927_RS20725 Protein ID WP_000626100.1
Coordinates 4218641..4219132 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag N5927_RS20730 Protein ID WP_001110452.1
Coordinates 4219129..4219422 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS20690 (4214101) 4214101..4214448 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
N5927_RS20695 (4214424) 4214424..4216127 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
N5927_RS20700 (4216164) 4216164..4216739 + 576 WP_001188509.1 transcriptional regulator -
N5927_RS20710 (4217010) 4217010..4217084 - 75 Protein_4046 helix-turn-helix domain-containing protein -
N5927_RS20715 (4217464) 4217464..4217541 + 78 Protein_4047 porin family protein -
N5927_RS20720 (4217641) 4217641..4218393 + 753 WP_000842433.1 non-specific acid phosphatase -
N5927_RS20725 (4218641) 4218641..4219132 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
N5927_RS20730 (4219129) 4219129..4219422 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
N5927_RS20735 (4219739) 4219739..4219960 + 222 WP_001576552.1 hypothetical protein -
N5927_RS20740 (4220226) 4220226..4221101 + 876 WP_000921676.1 AraC family transcriptional regulator -
N5927_RS20745 (4221098) 4221098..4221385 + 288 WP_001541332.1 transcriptional regulator RtsB -
N5927_RS20750 (4221378) 4221378..4221686 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
N5927_RS20755 (4221685) 4221685..4221933 + 249 Protein_4055 Ig-like domain-containing protein -
N5927_RS20760 (4222045) 4222045..4222176 + 132 Protein_4056 hypothetical protein -
N5927_RS20765 (4222470) 4222470..4223375 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T258755 WP_000626100.1 NZ_CP104641:c4219132-4218641 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT258755 WP_001110452.1 NZ_CP104641:c4219422-4219129 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References