Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4070620..4071170 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag N5927_RS19940 Protein ID WP_001199743.1
Coordinates 4070620..4070928 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag N5927_RS19945 Protein ID WP_001118105.1
Coordinates 4070931..4071170 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS19920 (4067194) 4067194..4067934 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
N5927_RS19925 (4068056) 4068056..4068586 - 531 WP_001708209.1 SEF14 fimbria major subunit SefA -
N5927_RS19930 (4068909) 4068909..4070042 + 1134 Protein_3895 IS3 family transposase -
N5927_RS19935 (4070074) 4070074..4070214 - 141 Protein_3896 Arm DNA-binding domain-containing protein -
N5927_RS19940 (4070620) 4070620..4070928 - 309 WP_001199743.1 CcdB family protein Toxin
N5927_RS19945 (4070931) 4070931..4071170 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N5927_RS19950 (4071279) 4071279..4071527 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
N5927_RS19955 (4071718) 4071718..4072149 - 432 Protein_3900 helix-turn-helix domain-containing protein -
N5927_RS19965 (4072906) 4072906..4073925 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
N5927_RS19970 (4073953) 4073953..4074483 - 531 WP_000896758.1 gluconokinase -
N5927_RS19975 (4074700) 4074700..4075731 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4069001..4072104 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T258753 WP_001199743.1 NZ_CP104641:c4070928-4070620 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT258753 WP_001118105.1 NZ_CP104641:c4071170-4070931 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References