Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4020345..4020921 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag N5927_RS19705 Protein ID WP_001131963.1
Coordinates 4020634..4020921 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag N5927_RS19700 Protein ID WP_000063142.1
Coordinates 4020345..4020647 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS19685 (4016855) 4016855..4019005 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
N5927_RS19690 (4019100) 4019100..4019303 + 204 WP_000460616.1 YbdD/YjiX family protein -
N5927_RS19695 (4019314) 4019314..4020270 + 957 WP_000187843.1 GTPase -
N5927_RS19700 (4020345) 4020345..4020647 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
N5927_RS19705 (4020634) 4020634..4020921 - 288 WP_001131963.1 BrnT family toxin Toxin
N5927_RS19710 (4021352) 4021352..4023193 + 1842 WP_000974637.1 nuclease-related domain-containing DEAD/DEAH box helicase -
N5927_RS19715 (4023806) 4023806..4024381 + 576 WP_000593784.1 restriction endonuclease subunit S -
N5927_RS19720 (4024386) 4024386..4025639 + 1254 WP_001206755.1 N-6 DNA methylase -
N5927_RS19725 (4025671) 4025671..4025805 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T258752 WP_001131963.1 NZ_CP104641:c4020921-4020634 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT258752 WP_000063142.1 NZ_CP104641:c4020647-4020345 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References